Nephrozoa is a major clade of bilateriananimals. It includes all bilaterians other than Xenacoelomorpha. It contrasts with the Xenambulacraria hypothesis, which instead posits that Xenacoelomorpha is most closely related to Ambulacraria.[1][2][3][4][5] Which hypothesis is correct has been debated. Authors supporting the Xenambulacraria hypothesis suggested in 2019 that the genetic evidence used to support Nephrozoa may be due to systematic error.[1] By 2024, the deuterostomes, the group in which the anus forms before the mouth in the early embryo, have been stated to be definitely a clade, fitting in with the Nephrozoa hypothesis (with Nephrozoa separate from Xenacoelomorpha).[6]
^Swalla, Billie J. (21 November 2024). "Deuterostome Ancestors and Chordate Origins". Integrative and Comparative Biology. 64 (5): 1175–1181. doi:10.1093/icb/icae134. PMID39104213.